Therefore, treat the parts of your earthly body as dead to sexual immorality, impurity, passion, evil desire, and greed, which amounts to idolatry."
When you go through your day, how often are you considering things above?
How often are you considering the Spiritual impact of your choices and decisions?
If indeed we believe the Bible, the whole Bible and nothing but the Bible, do you not believe this?
"For our struggle is not against flesh and blood, but against the rulers, against the powers, against the world forces of this darkness, against the spiritual forces of wickedness in the heavenly places." Ephesians 6:12 NASB
If you aren't focused on the things of God, what are you focusing on?
The Disciples were disoriented due to needing to be taught a new way of thinking. They didn't have the Holy Spirit yet. They were the first to be His workmanship.
We read this: Who knows the mind of God but the Spirit of God? If you have come to Christ for salvation then indeed you have the Spirit of God, the Helper who was promised.
Do you spend daily time with Jesus? Do you spend time reading your Bible? Do you at all set your mind on things above? If you aren't then you will indeed be beaten down by the things of this world. You won't be oriented to the things of God. You will indeed be always wondering why life is so hard. Why things make no sense at all. God gave us the Spirit to walk with us and be in us. It is because of the Spirit we have the full armor of God as the rest of the passage after Colossians 3:12 speaks to.
It's a learning process.
Don't expect to just wake up n think you can run out in the world and be the next Billy Graham. The Disciples marveled greatly at what abilities they had been granted and their results. Marveling isn't necessarily the same as understanding. I marvel greatly at the abilities that God's given me yet I am exceedingly reluctant to ever say that it's by my strength or wisdom I do what I am doing. Jesus makes the way, I try to follow in it in obedience. He connects the dots for me when His Spirit gives the understanding. Then my disorientation starts becoming orientation to the things of God.
We always will be disoriented to the world as long as we are oriented to the things of God. It only makes sense. We come to Christ we are no longer of this world. Does not Scripture say this: What does the light have to do with darkness? 2 Corinthians 6.
We have the light of Jesus to reveal the mind of God to a lost world. To show them how they too can be saved. Not to show them how to find health, wealth and prosperity. Indeed He may bless them in all of those things, but the greatest priority is to be saved. To know that the persons eternal address has changed. Then to Disciple them into a life that orients them to the life God intended for them.
Scripture also says that God isn't a God of confusion. If we don't know, then we ought to keep on praying and obeying what we've been given to do until we do get past the confusion.
Look at how oriented and disoriented you are in your walk with Jesus. Are you setting your mind on things above? Are you in prayer daily, not merely repeating the same thing without really meaning it? Are you reading your Bible at all daily? Without those two, how do you expect to be oriented to the things of God?